FLCN: A new regulator of AMPK-dependent Warburg metabolic reprogramming
نویسندگان
چکیده
Tumor cells manage their energy to support aberrant proliferation by reprogramming their cellular metabolism, for example through the Warburg effect. Although AMPK is a major regulator of energy homeostasis, its role in cancer metabolic adaptation is unclear. We recently identified the tumor suppressor folliculin as a new regulator of AMPK-dependent metabolic transformation.
منابع مشابه
The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation.
The Warburg effect is a tumorigenic metabolic adaptation process characterized by augmented aerobic glycolysis, which enhances cellular bioenergetics. In normal cells, energy homeostasis is controlled by AMPK; however, its role in cancer is not understood, as both AMPK-dependent tumor-promoting and -inhibiting functions were reported. Upon stress, energy levels are maintained by increased mitoc...
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عنوان ژورنال:
دوره 1 شماره
صفحات -
تاریخ انتشار 2014